J Neurol Sci. Jan 21;(1) Clinical diagnosis in Karwinskia humboldtiana polyneuropathy. Martínez HR(1), Bermudez MV, Rangel-Guerra RA. Toxicon. May;53(6) doi: /n Karwinskia humboldtiana (buckthorn) fruit causes central nervous system damage during. Karwinskia humboldtiana. Karwinskia humboldtiana (Schult.) Zucc. Coyotillo, Humboldt Coyotillo. Rhamnaceae (Buckthorn Family). Synonym(s).

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This Rhamnaceae article is a stub.

However, bumboldtiana often takes days or even weeks after consumption for the symptoms to manifest. It is native to southern and western Texas in the United States [2] as well as much of Mexico. Small wonder so many children in Mexico are poisoned by this common and deadly shrub.

The poisoning manifests itself as ascending paralysis, starting in the extremities and moving toward the trunk, and in extreme cases victims need mechanical assistance to breathe. However, consumption of fruit is much more deadly. Additionally, a cooked potion of the leaves was applied externally to infected wounds Martinez Their Environment and Material Culture. Coyotillo is a very poisonous plant, hujboldtiana stockmen know to introduce only livestock that are familiar with the vegetation of the region, or to feed plenty of supplements to those animals that aren’t.

It only takes 0. Goats, sheep, and cattle are all susceptible Lyons and Machen However, the leaves and the fruit, especially the seed inside the exocarp contain deadly neurotoxins.

We designed an open trial at the Pediatric Neurology service and included all cases with acute ascending paralysis that were admitted to our hospital in the last two years. The medical and veterinary literature is fuzzy about whether the seed is poisonous and the sweet pulp is harmless, or they are both poisonous.

Articles with ‘species’ microformats Commons category link from Wikidata Commons category link is on Wikidata All stub articles. University of Texas Press. This is the first report about the presence of neuronal damage kadwinskia by Kh in the Central Nervous System in chronic intoxication. These occurances beg the question: Coyotillo, Tullidora Karwinskia humboldtiana Schult. Only one patient required assisted ventilation due to bulbar paralysis.


Karwinskia humboldtiana – Wikipedia

In six cases, T Karwinskia humboldtiana toxin was detected. The literature is replete with examples of coyotillo poisoning in both livestock and humans. Clinical diagnosis in poisoned humans may be difficult if no evidence of previous fruit ingestion is available. The availability of toxin detection in blood samples allows the clinician to establish an accurate diagnosis and humboldtiaan be included in the study of children with polyradiculoneuropathy, especially in countries where this poisonous plant grows.

But an experiment conducted on livestock clearly illustrates how the dangers of karwinsiia fruit.

Children exhibiting symptoms of coyotillo poisoning, including shakes or “palsies” were seen by outside observers. Studies have shown that the coyotillo T neurotoxin is detectable in the bloodstream of victims, which is important because the symptoms may be caused by other pathologies Martinez, et al.

My concern is hhumboldtiana the relaxation might well be permanent. In our ,arwinskia work we fed the ground Kh fruit to Wistar rats and samples of brain, cerebellum, and pons were embedded in paraffin.

However, raccoon, coyote, and fox appear to eat the berries and survive, because the scat of these animals is loaded with coyotillo seeds when the fruit is ripe. New York, New York: We present our experience in the clinical diagnosis of Karwinskia humboldtiana polyneuropathy, as confirmed by toxin detection in blood. At any rate, this is not a fruit that anyone should ingest or even put in their mouth Bermudez et al. From Wikipedia, the free encyclopedia.

I do not know how lethal coyotillo is in humans, but 0. In this polyneuropathy the lesion demyelization in peripheral nerves has been described in several animal species, both in acute and in chronic intoxication. In two of these cases, a sural nerve biopsy revealed a segmental demyelination with swelling and phagocytic chambers in Schwann cells and without lymphocytic infiltration. Karwinskia humboldtianacommonly known as coyotillocacachila or Humboldt coyotillois a species of flowering shrub or small tree in the buckthorn family, Rhamnaceae.


Coyotillo is a small, evergreen shrub with deep green, almost glossy and distinctively veined leaves that grow opposite each other along the stem.

Coyotillo, Tullidora

We conclude that this intoxication is common in Mexico. However, he does note that a tincture of the leaves was karsinskia as an anticonvulsive for treating paralysis from tetanus, until the muscles relax. This page was last edited on 25 Augustat Algonquin Books of Chapel Hill.

Tragically, children are its most common victims. Therefore it takes weeks for the animal to show symptoms from coyotillo foliage consumption.

Plant Database

There is a curious and telling reference to coyotillo use by the Tarahumara. With this methodology, we found lesions in the motor pathway.

These cases had a symmetric motor polyneuropathy with the absence of tendon reflexes and no sensory signs or cranial nerve involvement. Karwinskia humboldtiana Scientific classification Kingdom: We considered it important to evaluate, with histological techniques, the possible presence of lesions in the brain, by using a model of chronic intoxication that reproduces the same stages present in the human intoxication, to better understanding of this pathological process.

Languages Cebuano Svenska Winaray Edit links. The presence of Karwinskia humboldtiana toxins in blood were determined by thin layer chromatography. It was actually eaten as starvation food in June, but over-consumption caused a serious stomach ache.

Wikimedia Commons has media related to Karwinskia humboldtiana. Histopathological changes were evaluated in the CNS through the different stages of the polyneuropathy and comparison to a control group.

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